1. Estrogen

Higher amounts of estrogen may lead to more histamine issues because estrogen can bind to mast cells and stimulate the release of histamines. Estrogen can also down-regulate DAO, which is an enzyme that helps to break down histamines.

2. Histamine

Histamine can bind to the ovaries and stimulate more estrogen. It can also aid in the overproduction of Luteinizing Hormones.

3. Stop The Cycle

In order to stop this cycle you must first understand the root cause. Is it digestive issues, hormonal imbalances, or something else? Ways you can assist in healing this are to cut out alcohol, fermented foods, fix digestive system issues, increase progesterone, and add more cruciferous vegetables to your diet.