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3583: Is Melatonin Dangerous for Your Heart?

  • November 27, 2025

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TT: Is Melatonin Dangerous for Your Heart?

You may have seen recent headlines claiming melatonin could harm your heart, but is it really dangerous, or just sensationalized media?

On today’s show, we break down the latest observational study and compare it with decades of research highlighting melatonin’s benefits.

We’ll cover why context, dosage, and underlying health conditions matter, and explore how melatonin can support heart health, blood pressure, sleep quality, immune function, and even cellular longevity.

Join me on today’s Cabral Concept 3583 to cut through the fear-based headlines, understand the science, and decide if melatonin is right for you.

Enjoy the show!

Show Highlights & Big Takeaways:

1. Observational Studies Can Be Misleading
The recent heart-risk study on melatonin was observational, not cause-and-effect, and likely confounded by pre-existing cardiovascular and sleep issues. Context and dosage matter.

2. Melatonin Supports many Different Aspects
Research shows melatonin improves blood pressure, endothelial function, mitochondrial health, circadian rhythm, sleep quality, and immune function, including natural killer cell activity.

3. Anti-aging and Cellular Protection
Studies also show that Melatonin reduces inflammation, supports cellular longevity, and enhances circadian regulation.

Show Notes & Related Podcasts

Long-term use of melatonin supplements to support sleep may have negative health effects | American Heart Association

Melatonin and Nicotinamide Mononucleotide Attenuate Myocardial Ischemia/Reperfusion Injury via Modulation of Mitochondrial Function and Hemodynamic Parameters in Aged Rats – PubMed

Melatonin protects cardiac microvasculature against ischemia/reperfusion injury via suppression of mitochondrial fission-VDAC1-HK2-mPTP-mitophagy axis – PubMed

Melatonin, mitochondria and hypertension – PubMed

Effect of melatonin on nocturnal blood pressure: meta-analysis of randomized controlled trials – PubMed

Meta-Analysis: Melatonin for the Treatment of Primary Sleep Disorders – PMC

Melatonin enhances NK cell function in aged mice by increasing T-bet expression via the JAK3-STAT5 signaling pathway – PubMed

Therapeutic application of melatonin in mild cognitive impairment – PubMed

Podcast on Melatonin

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