3233: The Root Cause of Sex Hormone Binding Globulin (SHGB)

December 12, 2024

3233: The Root Cause of Sex Hormone Binding Globulin (SHGB)

December 12, 2024

TT: The Root Cause of Sex Hormone Binding Globulin (SHGB)

We frequently see individuals in our practice with low testosterone or estrogen levels.

If you are not in menopause or andropause, it’s essential to uncover the root cause of these lower hormone levels.

One potential factor is a protein called SHBG (sex hormone-binding globulin), which binds to sex hormones and can contribute to reduced levels.

So today, I want to share the 3 main reasons SHBG levels may increase and discuss what you can do to address it.

Join me on today’s Cabral Concept 3233 as we explore the root causes of elevated SHBG. Enjoy the episode, and I’d love to hear your thoughts!

Show Highlights & Big Takeaways

1. Overall Testosterone & Estrogen Levels

Overall testosterone and estrogen levels impact SHBG production. In males, high estrogen levels can increase SHBG, and when testosterone is converted to estrogen, SHBG levels rise further, binding more testosterone and reducing its availability in the body.

2. Liver Congestion

Liver congestion can impair the liver’s ability to produce adequate levels of sex hormone-binding globulin (SHBG), leading to increased levels of free hormones like testosterone and estrogen. This imbalance can exacerbate hormonal disorders and contribute to increased inflammation.

3. Imbalanced Thyroid Levels

Elevated levels of T3 can lead to an increase in SHBG. When the body is in a greater state of metabolic stress, it often produces more thyroid hormone, which can influence SHBG levels and potentially create hormonal imbalances.