Study by G. Varani et al. (2006): This study, published in the “Journal of Investigative Dermatology,” found that collagen production in aged human skin fibroblasts is significantly reduced. It was observed that aged skin produces less collagen compared to younger skin.

Research on Skin Biopsies: Studies involving skin biopsies from different age groups have shown a decline in collagen content and density. For example, research published in “Dermato-Endocrinology” (2012) by K. Rittié found that collagen levels in the dermis decrease with age, contributing to the signs of skin aging.

Advanced Glycation End Products (AGEs): Accumulation of AGEs in the skin can lead to collagen cross-linking, making it less elastic and more prone to breakage. This process also contributes to the visible signs of aging.

Bone Health and Collagen: Collagen is a major component of bone tissue. Studies on bone health have shown that collagen content decreases with age, affecting bone density and strength. Research published in “Osteoporosis International” (2009) by N. Boskey and R. Coleman highlights the role of collagen in maintaining bone integrity and how its decline can contribute to osteoporosis.

Supplementation and Collagen Production: Several studies have investigated the effects of collagen supplements on skin health. A systematic review published in the “Journal of Drugs in Dermatology” (2019) found that oral collagen supplementation can improve skin elasticity, hydration, and dermal collagen density in older adults.

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