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3450: Beyond Basic Cholesterol: Run These Advanced Heart Health Panels

  • July 17, 2025

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TT: Beyond Basic Cholesterol: Run These Advanced Heart Health Panels

Is your annual cholesterol test giving you the full picture of your heart health?

While conventional lab work is important, it often overlooks deeper, more predictive markers of cardiovascular risk.

On today’s episode, I’ll walk you through the most advanced heart health labs that go beyond the basic lipid panel.

You’ll learn which markers truly matter, what they reveal about your risk for heart disease, and how to take meaningful action.

Join me on today’s Cabral Concept 3450 to discover the hidden cardiovascular labs most doctors miss—and why they’re essential for long-term wellness.

Enjoy the show, and let me know what you think!

Show Highlights & Big Takeaways:

Apolipoprotein B (ApoB): ApoB is the single most important marker for predicting heart disease risk. Aim to keep this number under 80 mg/dL.

LDL Particle Number (LDL-P): LDL-P shows how many LDL particles are circulating in your blood. More particles can mean more risk, so it’s best to stay below 1,000 nmol/L.

Lipoprotein(a): Lipoprotein is a genetic marker that can triple your risk for heart disease. Ideally, this number should be below 30 mg/dL.

Oxidized LDL: Oxidized LDL reflects how damaged your cholesterol is by inflammation. The goal is to keep this under 100–110 to reduce arterial damage.

High-Sensitivity C-Reactive Protein (hs-CRP): Hs-CRP is a key inflammation marker. It should be below 1.0 mg/L, but ideally closer to 0.5.

Homocysteine: Homocysteine is a marker of inflammation in your blood vessels and poor methylation. Try to keep it in the range of 6.5 to 8.5 µmol/L.

Fasting Insulin: Fasting Insulin measures how well your body manages blood sugar. Optimal levels are between 2 and 6 µIU/mL.

Triglycerides: Triglycerides are fats in your blood, and high levels can increase heart risk. A healthy range is between 50 and 75 mg/dL.

HDL Cholesterol (the “good” cholesterol): HDL helps protect your heart. Aim to keep it above 59 mg/dL.

Cholesterol to HDL Ratio: This ratio is calculated by dividing total cholesterol by HDL. A ratio of 3:1 or lower is ideal.

Triglyceride to HDL Ratio: This ratio shows your metabolic health. It should be below 2:1, but a 1:1 ratio is even better.

VLDL (Very Low-Density Lipoprotein): VLDL is a harmful form of cholesterol. Lower levels are better because it contributes to plaque buildup.

Small Dense LDL Particles: Small LDL particles can easily penetrate artery walls and cause inflammation. Fewer and larger LDL particles are less risky.

HDL Particle Number (HDL-P): HDL-P tells you how many HDL particles you have, not just how much HDL cholesterol. Higher particle numbers offer more heart protection.

VLDL Particle Number (VLDL-P): VLDL-P measures how many dangerous VLDL particles are in your blood. Keeping this number low helps reduce inflammation and triglyceride-related risk.

Show Notes & Related Podcasts

Podcast on Blood Work You Should Run

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