3620: Leucovorin & Autism, Bovine Collagen, Mitochondrial Testing, Cold Plunge & Stress, Histamine Intolerance & Allergies

January 3, 2026

3620: Leucovorin & Autism, Bovine Collagen, Mitochondrial Testing, Cold Plunge & Stress, Histamine Intolerance & Allergies

January 3, 2026

HouseCall: Leucovorin & Autism, Bovine Collagen, Mitochondrial Testing, Cold Plunge & Stress, Histamine Intolerance & Allergies

Welcome back to our weekend Cabral HouseCall shows!

This is where we answer our community’s wellness, weight loss, and anti-aging questions to help people get back on track!

Check out today’s questions:

Arianne: Hi Dr. Cabral, First, I want to say thank you for all of your resources! I start every day with your podcast – it is truly the best out there! My question is regarding the medication, Leucovorin, and its use in treating Autism. I have a 3 year old son who is non-verbal and is moderately Autistic. His pediatrician has prescribed Leucovorin on a titration schedule where he will be monitored for its effects. To note my own lab results, I have MTHFR, high levels of mercury and aluminum, low electrolytes/minerals, anemia/low ferritin, and gut issues – likely these were passed along to my son. I plan to have him complete the labs now that he is old enough. What is your advice on Leucovorin and its safety & efficacy, also should I be concerned with potential fillers and aluminum in the drug?

Sheena: Hi Dr C! Hope you and your team are well. I was just wondering if all bovine collagen has protein in it, even if it doesn’t say it on the label? And if so, does the protein count towards my daily protein intake? Thank you so much in advance for answering!

Jonny: Hello Dr. Cabral, Recently done some mitochondrial testing and found that my complex 2+3 are operating at 16% activity, and complex 2 at 58%, so there unable to turn substrate into energy efficiently. I’m wondering if you have any advice. Currently dealing with CIRS, Sibo/dysbiosis/chronic stress/Trauma. Non starchy carbs make me jittery, as well as stressors in general, but it’s not blood sugar, as I’ve worn monitors and my levels seem fairly ideal. I think it’s the CIRS jitters, shakiness that I’ve heard you speak of. I just got your new book, so I’m going to read through that for any tips. Already taking adrenal soothe, working with a therapist, doing my best to lower the stressors in my life. I know 90-120 days for red blood cell/mitochondrial turnover, so things can take time. Thanks

Anonymous: Hi Dr. Cabral, I’ve heard conflicting advice on cold plunging for people with high stress or adrenal dysregulation. How to you determine if cold exposure if supportive or not. Thanks!

Sarah: I’m curious about histamine intolerance and allergies. why do some people suddenly develop reactions to something that haven’t had all their lives. I used to not be allergic to horses for instance, I could ride them when I was younger, but now I can’t even be in the same room with someone who has been around them. Thanks for your help.

Thank you for tuning into today’s Cabral HouseCall and be sure to check back tomorrow where we answer more of our community’s questions!