3632: Why Methylation Supplements Usually Backfire
January 15, 2026
3632: Why Methylation Supplements Usually Backfire
January 15, 2026
TT:
Could the very supplements meant to support your methylation be working against you?
On today’s episode, I uncover a major misunderstanding about methylation and why supplements like methyl folate (B9) and B12 don’t always work the way people expect them to.
I explain why simply adding more methyl donors isn’t enough, how missing foundational nutrients can create unwanted symptoms, and what most people are overlooking when trying to support their brain, energy, and nervous system.
So join me for today’s Cabral Concept 3632 to learn why methylation supplements usually backfire, how to properly support methylation, and how to avoid one of the most common supplement mistakes I see in practice.
Enjoy the show, and as always, let me know your thoughts!
Show Highlights & Big Takeaways
1. B9 and B12 Alone Aren’t Enough: These vitamins are carriers, not the solution. Without the proper cofactors and pathways, they can’t fully support methylation.
2. Riboflavin (B2) and B6 are Critical: B2 acts as the engine that moves B vitamins where they need to go, and B6 supports neurotransmitter production and overall balance.
3. Foundational Supplementation is Key: A full B complex, combined with omega-3s and vitamin D3, is more effective than single or cherry-picked supplements for supporting methylation, energy, and overall health.
